PEG-PLGA, PEG 5k & PLGA 10k, L:G 3:1
PEG-PLGA is an amphiphilic AB diblock copolymer consisting of a hydrophilic block polyethylene glycol (PEG) or polyethylene oxide (PEO) and a hydrophobic block poly(lactide-co-glycolide) (PLGA). The PEG polymer is capped a methyl ether group, and the hydrophobic block terminates with a hydroxyl group. PEGylated copolymers with biodegradable and biocompatible polyester segments can be used to prepare core-shell micelles, nanoparticles and microspheres. The hydrolytic degradability of polyester segments depend on the molecular weight and the spacer between ester groups (lactide, glycolide or caprolactone). PEG-PLGA with other MWs is also offered. References: 1. Inhibition of Karyopherin beta 1 suppresses prostate cancer growth, Nature Oncogene, 2019, doi: 10.1038/s41388-019-0745-22. Strategies to enhance the distribution of nanotherapeutics in the brain, Journal of Controlled Release, 2017,10.1016/j.jconrel.2017.07.028, Text.3. Biodegradable long-circulating polymeric nanospheres. Science 1994;363:1600–3, Text.