Monoclonal Mouse Anti-Human PD-L1 Clone 22C3
Intended use :Analytic Specific Reagent. Analytical and performance characteristics are not established. Synonyms for antigen :Programmed Death-Ligand 1. Summary
and explanation :Binding of the PD-1 ligands, PD-L1 and PD-L2, to the PD-1 receptor found on T cells, inhibits T cell
proliferation and cytokine production (1). Reagent provided :Monoclonal mouse antibody provided in liquid form in 0.05 mol/L Tris-HCl, 0.015 mol/L sodium azide, 1%
bovine serum albumin, pH 7.2.
Clone: 22C3 (5). Isotype: IgG1.
Mouse IgG concentration mg/L: See label on vial. Immunogen :Human extracellular domain of PD-L1 (Phe19-Thr239) fused to a human IgG1 fragment (R&D Systems
Catalogue No. 156-B7-100) (2) Specificity :In Western blotting of recombinant human PD-L1 protein, Monoclonal Mouse Anti-Human PD-L1, Clone 22C3
labels a band corresponding to ~40 kDa (2). Precautions :1. For professional users.2. This product contains sodium azide (NaN3), a chemical highly toxic in pure form. At product concentrations,
though not classified as hazardous, sodium azide may react with lead and copper plumbing to form highly
explosive build-ups of metal azides. Upon disposal, flush with large volumes of water to prevent metal azide
build-up in plumbing. 3. As with any product derived from biological sources, proper handling procedures should be used. 4. Wear appropriate Personal Protective Equipment to avoid contact with eyes and skin. 5. Unused solution should be disposed of according to local, State and Federal regulations.Storage :Store at 2-8 °C. Do not use after expiration date s tamped on vial. If reagents are stored under any conditions
other than those specified, the conditions must be verified by the user. There are no obvious signs to indicate
instability of this product. References 1. Brown JA, Dorfman DM, Ma F-R, Sullivan EL, Munoz O, Wood CR, et al. Blockade of Programmed
Death-1 Ligands on Dendritic Cells Enhances T Cell Activation and Cytokine Production. J Immunol
2003;170:1257.2. Ellison AR. Technical Report: Characterization of monoclonal mouse anti-PD-L1 antibody clone 22C3.