硫酸钠葡聚糖(DSS) Dextran Sulfate Sodium Salt (36,000-50,000 M.Wt.)促销
Dextran sulfate sodium salt, or DSS, is a branched glucan that triggers colitis in mice and rats when administered in drinking water. DSS binds to medium-chain-length fatty acids in the colon and induces intestinal inflammation. Dextran sulfate sodium is also used to precipitate lipoproteins and to release DNA from DNA-histone complexes.Application NotesDextran Sulfate Sodium (DSS) is proven to have versatile value in biomedical/clinical research. DSS can be used to study colitis (Inflammatory Bowel disease) in research animals and can also be used as an antiviral agent. Inflammatory Bowel Disease (IBD) is characterized by chronic and relapsing inflammation of the gastrointestinal tract and is associated with increased risk of developing colitis-associated cancer. Several animal models have been used to study colitis and one such method involves the oral administration of dextran sulfate sodium (DSS) in the drinking water of mice, leading to chronic colitis. This DSS induced colitis model is spontaneous and is used to assess the therapeutic potential of treatments for IBD. Bamba et al (2012) performed a comparative analysis of 3 different DSS preparations to examine the chemical and cytotoxic properties, as well as the severity of colitis. Their study concluded that the DSS from MP Bio induced severe colitis as indicated by body weight transition, DAI score, colon weight/length and histological scores. This DSS is well characterized and offers the highest sulfur content (19%), highest chirality (+104 ° of specific rotation), and lowest pH (6.2 at 1% solution).Usage StatementResearch Use Only (RUO). Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animalsKey ApplicationsColitis, Antilipemic硫酸葡聚糖钠盐或DSS是支链葡聚糖,当在饮用水中给药时,其在小鼠和大鼠中引发结肠炎。DSS与结肠中的中链长脂肪酸结合并诱导肠道炎症。硫酸葡聚糖钠也用于沉淀脂蛋白并从DNA-组蛋白复合物中释放DNA。应用笔记葡聚糖硫酸钠(DSS)被证明在生物医学/临床研究中具有多种价值。DSS可用于研究研究动物的结肠炎(炎症性肠病),也可用作抗病毒剂。炎症性肠病(IBD)的特征在于胃肠道的慢性和复发性炎症,并且与发生结肠炎相关癌症的风险增加相关。已经使用几种动物模型来研究结肠炎,并且一种这样的方法涉及在小鼠的饮用水中口服硫酸葡聚糖钠(DSS),导致慢性结肠炎。该DSS诱导的结肠炎模型是自发的并且用于评估IBD治疗的治疗潜力。Bamba等(2012)对3种不同的DSS制剂进行了对比分析,以检测化学和细胞毒性以及结肠炎的严重程度。他们的研究得出结论,来自MP Bio的DSS诱导了严重的结肠炎,如体重转换,DAI评分,结肠重量/长度和组织学评分所示。该DSS具有良好的特性,具有*高的硫含量(19%),*高的手性(特定旋转+104°)和*低的pH值(6.2%的1%溶液)。使用声明仅供研究使用(RUO)。除非我们的目录或产品随附的其他公司文档中另有说明,否则我们的产品仅供研究使用,不得用于任何其他目的,包括但不限于未经授权的商业用途,体外诊断用途,离体或体内治疗用途或任何类型的消费或应用于人或动物主要应用结肠炎,抗血脂